Discovery of Chemoselective and Biocompatible Reactions Using a High‐Throughput Immunoassay Screening | Zendy

Kolodych Sergii | Zendy; Rasolofonjatovo Evelia | Zendy; Chaumontet Ma | Zendy; Nevers MarieClaire | Zendy; Crémi Christophe | Zendy; Taran Frédéric | Zendy

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Discovery of Chemoselective and Biocompatible Reactions Using a High‐Throughput Immunoassay Screening

Author(s) -

Kolodych Sergii,

Rasolofonjatovo Evelia,

Chaumontet Ma,

Nevers MarieClaire,

Crémi Christophe,

Taran Frédéric

Publication year - 2013

Publication title -

angewandte chemie international edition

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 5.831

H-Index - 550

eISSN - 1521-3773

pISSN - 1433-7851

DOI - 10.1002/anie.201305645

Subject(s) - biocompatible material , immunoassay , alkyne , sydnone , combinatorial chemistry , chemistry , cycloaddition , nanotechnology , catalysis , materials science , organic chemistry , engineering , biomedical engineering , medicine , ring (chemistry) , antibody , immunology

An immunoassay‐based method was used to screen numerous combinations of dipoles and dipolarophiles for their ability to undergo chemoselective and biocompatible [3+2] cycloaddition reactions. The approach fulfills most of the requirements of the click concept and led to the discovery of a copper‐catalyzed reaction that generates pyrazoles from sydnone and alkyne reagents.

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