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Discovery of Chemoselective and Biocompatible Reactions Using a High‐Throughput Immunoassay Screening
Author(s) -
Kolodych Sergii,
Rasolofonjatovo Evelia,
Chaumontet Ma,
Nevers MarieClaire,
Crémi Christophe,
Taran Frédéric
Publication year - 2013
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201305645
Subject(s) - biocompatible material , immunoassay , alkyne , sydnone , combinatorial chemistry , chemistry , cycloaddition , nanotechnology , catalysis , materials science , organic chemistry , engineering , biomedical engineering , medicine , ring (chemistry) , antibody , immunology
An immunoassay‐based method was used to screen numerous combinations of dipoles and dipolarophiles for their ability to undergo chemoselective and biocompatible [3+2] cycloaddition reactions. The approach fulfills most of the requirements of the click concept and led to the discovery of a copper‐catalyzed reaction that generates pyrazoles from sydnone and alkyne reagents.