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Catalytic Enantioselective Synthesis of Tertiary Thiols From 5 H ‐Thiazol‐4‐ones and Nitroolefins: Bifunctional Ureidopeptide‐Based Brønsted Base Catalysis
Author(s) -
Diosdado Saioa,
Etxabe Julen,
Izquierdo Joseba,
Landa Aitor,
Mielgo Antonia,
Olaizola Iurre,
López Rosa,
Palomo Claudio
Publication year - 2013
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201305644
Subject(s) - bifunctional , enantioselective synthesis , catalysis , brønsted–lowry acid–base theory , base (topology) , chemistry , organic chemistry , combinatorial chemistry , mathematics , mathematical analysis
Fully loaded : The ureidopeptide‐based bifunctional Brønsted base 1 efficiently promotes the first direct catalytic Michael reaction of α‐mercapto carboxylate surrogates with nitroolefins involving a fully substituted α‐carbon atom construction.