Biosynthesis of the Antimetabolite 6‐Thioguanine in  Erwinia amylovora  Plays a Key Role in Fire Blight Pathogenesis | Zendy

Coyne Sébastien | Zendy; Chizzali Cornelia | Zendy; Khalil Mohammed N. A. | Zendy; Litomska Agnieszka | Zendy; Richter Klaus | Zendy; Beerhues Ludger | Zendy; Hertweck Christian | Zendy

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Biosynthesis of the Antimetabolite 6‐Thioguanine in Erwinia amylovora Plays a Key Role in Fire Blight Pathogenesis

Author(s) -

Coyne Sébastien,

Chizzali Cornelia,

Khalil Mohammed N. A.,

Litomska Agnieszka,

Richter Klaus,

Beerhues Ludger,

Hertweck Christian

Publication year - 2013

Publication title -

angewandte chemie international edition

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 5.831

H-Index - 550

eISSN - 1521-3773

pISSN - 1433-7851

DOI - 10.1002/anie.201305595

Subject(s) - fire blight , erwinia , biology , antimetabolite , pathogenesis , microbiology and biotechnology , biosynthesis , heterologous , bacteria , biochemistry , genetics , gene , immunology , chemotherapy

Sulfur for fire : The molecular basis for the biosynthesis of the antimetabolite 6‐thioguanine (6TG) was unveiled in Erwinia amylovora , the causative agent of fire blight. Bioinformatics, heterologous pathway reconstitution in E. coli , and mutational analyses indicate that the protein YcfA mediates guanine thionation in analogy to 2‐thiouridylase. Assays in planta and in cell cultures reveal for the first time a crucial role of 6TG in fire blight pathogenesis.

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