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Multiplexing of Combinatorial Chemistry in Antimycin Biosynthesis: Expansion of Molecular Diversity and Utility
Author(s) -
Yan Yan,
Chen Jing,
Zhang Lihan,
Zheng Qingfei,
Han Ying,
Zhang Hua,
Zhang Daozhong,
Awakawa Takayoshi,
Abe Ikuro,
Liu Wen
Publication year - 2013
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201305569
Subject(s) - biosynthesis , computer science , computational biology , diversification (marketing strategy) , chemistry , combinatorial synthesis , combinatorial chemistry , biochemistry , biology , gene , business , marketing
Diversity‐oriented biosynthesis of a library of antimycin‐like compounds (380 altogether) was accomplished by using multiplex combinatorial biosynthesis. The core strategy depends on the use of combinatorial chemistry at different biosynthetic stages. This approach is applicable for the diversification of polyketides, nonribosomal peptides, and the hybrids that share a similar biosynthetic logic.