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A Nucleobase Analogue that Pairs Strongly with Adenine
Author(s) -
Minuth Marco,
Richert Clemens
Publication year - 2013
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201305555
Subject(s) - nucleobase , chemistry , stereochemistry , combinatorial chemistry , dna , biochemistry
Shaping up for an A : Adenine is the only canonical nucleobase that does not offer a third hydrogen‐bonding functionality at its Watson–Crick face, making it difficult to bind with high affinity. A 6‐ethynyl‐2‐pyridone binds more tightly and with greater sequence fidelity than thymine. VdW=van der Waals interactions.
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