Structure‐Based Gene Targeting Discovery of Sphaerimicin, a Bacterial Translocase I Inhibitor | Zendy

Funabashi Masanori | Zendy; Baba Satoshi | Zendy; Takatsu Toshio | Zendy; Kizuka Masaaki | Zendy; Ohata Yasuo | Zendy; Tanaka Masahiro | Zendy; aka Koichi | Zendy; Spork Anatol P. | Zendy; Ducho Christian | Zendy; Chen WeiChen Leyla | Zendy; Van Lanen Steven G. | Zendy

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Structure‐Based Gene Targeting Discovery of Sphaerimicin, a Bacterial Translocase I Inhibitor

Author(s) -

Funabashi Masanori,

Baba Satoshi,

Takatsu Toshio,

Kizuka Masaaki,

Ohata Yasuo,

Tanaka Masahiro,

aka Koichi,

Spork Anatol P.,

Ducho Christian,

Chen WeiChen Leyla,

Van Lanen Steven G.

Publication year - 2013

Publication title -

angewandte chemie international edition

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 5.831

H-Index - 550

eISSN - 1521-3773

pISSN - 1433-7851

DOI - 10.1002/anie.201305546

Subject(s) - translocase , chemistry , uridine , threonine , biochemistry , gene , computational biology , biophysics , biology , chromosomal translocation , rna , enzyme , serine

Rise and shine : Using a gene‐targeting approach aimed at identifying potential L ‐threonine:uridine‐5′‐transaldolases that catalyze the formation of (5′ S ,6′ S )‐ C ‐glycyluridine, a new bacterial translocase I inhibitor was discovered from an actinomycete following fermentation optimization.

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