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Structure‐Based Gene Targeting Discovery of Sphaerimicin, a Bacterial Translocase I Inhibitor
Author(s) -
Funabashi Masanori,
Baba Satoshi,
Takatsu Toshio,
Kizuka Masaaki,
Ohata Yasuo,
Tanaka Masahiro,
aka Koichi,
Spork Anatol P.,
Ducho Christian,
Chen WeiChen Leyla,
Van Lanen Steven G.
Publication year - 2013
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201305546
Subject(s) - translocase , chemistry , uridine , threonine , biochemistry , gene , computational biology , biophysics , biology , chromosomal translocation , rna , enzyme , serine
Rise and shine : Using a gene‐targeting approach aimed at identifying potential L ‐threonine:uridine‐5′‐transaldolases that catalyze the formation of (5′ S ,6′ S )‐ C ‐glycyluridine, a new bacterial translocase I inhibitor was discovered from an actinomycete following fermentation optimization.