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A Powerful Hydrogen‐Bond‐Donating Organocatalyst for the Enantioselective Intramolecular Oxa‐Michael Reaction of α,β‐Unsaturated Amides and Esters
Author(s) -
Kobayashi Yusuke,
Taniguchi Yamato,
Hayama Noboru,
Inokuma Tsubasa,
Takemoto Yoshiji
Publication year - 2013
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201305492
Subject(s) - enantioselective synthesis , intramolecular force , chemistry , michael reaction , organocatalysis , organic chemistry , catalysis , hydrogen bond , combinatorial chemistry , molecule
Tuning the organocatalyst : An unprecedented enantioselective intramolecular oxa‐Michael reaction of unactivated α,β‐unsaturated amides and esters catalyzed by a powerful hydrogen‐bond‐donating organocatalyst has been developed. Furthermore, the products obtained from this reaction have been used for the straightforward asymmetric synthesis of several natural products and biologically important compounds.