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End‐to‐End Continuous Manufacturing of Pharmaceuticals: Integrated Synthesis, Purification, and Final Dosage Formation
Author(s) -
Mascia Salvatore,
Heider Patrick L.,
Zhang Haitao,
Lakerveld Richard,
Benyahia Brahim,
Barton Paul I.,
Braatz Richard D.,
Cooney Charles L.,
Evans James M. B.,
Jamison Timothy F.,
Jensen Klavs F.,
Myerson Allan S.,
Trout Bernhardt L.
Publication year - 2013
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201305429
Subject(s) - continuous flow , process engineering , pharmaceutical manufacturing , active ingredient , dosage form , product (mathematics) , chemistry , biochemical engineering , chromatography , engineering , pharmacology , mathematics , medicine , geometry
A series of tubes : The continuous manufacture of a finished drug product starting from chemical intermediates is reported. The continuous pilot‐scale plant used a novel route that incorporated many advantages of continuous‐flow processes to produce active pharmaceutical ingredients and the drug product in one integrated system.