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Palladium‐Catalyzed ortho ‐Selective CH Deuteration of Arenes: Evidence for Superior Reactivity of Weakly Coordinated Palladacycles
Author(s) -
Ma Sandy,
Villa Giorgio,
ThuyBoun Peter S.,
Homs Anna,
Yu JinQuan
Publication year - 2014
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201305388
Subject(s) - reactivity (psychology) , palladium , chemistry , catalysis , phenylacetic acid , benzoic acid , deuterium , medicinal chemistry , organic chemistry , medicine , physics , alternative medicine , pathology , quantum mechanics
We disclose a protocol for the palladium‐catalyzed ortho ‐selective CH deuteration of arenes. Phenylacetic acids and benzoic acids are suitable substrates for this reaction. This reaction offers a catalytic route to ortho ‐deuterated phenylacetic acids and benzoic acids and demonstrates the sharp difference in reactivity of palladacycle intermediates held together by weak and strong coordination.