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Elucidating the Neurotoxicity of the Star Fruit
Author(s) -
GarciaCairasco Norberto,
MoysesNeto Miguel,
Del Vecchio Flavio,
Oliveira José A. C.,
dos Santos Francisco L.,
Castro Olagide W.,
Arisi Gabriel M.,
Dantas Márcio,
Carolino Ruither O. G.,
CoutinhoNetto Joaquim,
Dagostin Andre L. A.,
Rodrigues Marcelo C. A.,
Leão Ricardo M.,
Quintiliano Samir A. P.,
Silva Luiz F.,
GobboNeto Leonardo,
Lopes Norberto P.
Publication year - 2013
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201305382
Subject(s) - neurotoxicity , computer science , neuroscience , medicine , psychology , toxicity
Caramboxin : Patients suffering from chronic kidney disease are frequently intoxicated after ingesting star fruit. The main symptoms of this intoxication are named in the picture. Bioguided chemical procedures resulted in the discovery of caramboxin, which is a phenylalanine‐like molecule that is responsible for intoxication. Functional experiments in vivo and in vitro point towards the glutamatergic ionotropic molecular actions of caramboxin, which explains its convulsant and neurodegenerative properties.