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The Catalytically Active Copper‐Amyloid‐Beta State: Coordination Site Responsible for Reactive Oxygen Species Production
Author(s) -
Cassagnes LaureEstelle,
Hervé Vincent,
Nepveu Françoise,
Hureau Christelle,
Faller Peter,
Collin Fabrice
Publication year - 2013
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201305372
Subject(s) - reactive oxygen species , context (archaeology) , amyloid (mycology) , copper , chemistry , oxygen , mechanism (biology) , biophysics , biochemistry , biology , inorganic chemistry , organic chemistry , paleontology , philosophy , epistemology
Copper‐amyloid‐β ROS production : Copper ions (red sphere, see picture) have been found to accumulate in amyloid‐β plaques and play a role in the generation of reactive oxygen species (ROS) within this context. Mass spectrometry studies were able to detail the sites of oxidation damage and shed new light on the mechanism of ROS production, important for the understanding of the pathogenicity of amyloid‐β peptides.