Premium
Palladium‐Catalyzed Three‐Component Diaryl Sulfone Synthesis Exploiting the Sulfur Dioxide Surrogate DABSO
Author(s) -
Emmett Edward J.,
Hayter Barry R.,
Willis Michael C.
Publication year - 2013
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201305369
Subject(s) - xantphos , aryl , palladium , sulfur dioxide , catalysis , sulfone , chemistry , ligand (biochemistry) , combinatorial chemistry , halide , sulfur , component (thermodynamics) , lithium (medication) , organic chemistry , physics , medicine , biochemistry , alkyl , receptor , thermodynamics , endocrinology
SO(2) efficient : A three‐component palladium‐catalyzed coupling of aryl lithium compounds; sulfur dioxide (provided by the easy‐to‐handle solid surrogate, DABSO); and aryl, heteroaryl, and alkenyl (pseudo)halides yields a diverse library of sulfones. An electron‐poor XantPhos‐type ligand suppresses aryl–aryl exchange and is key to obtaining high yields.