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Single‐Molecule Analysis of the Recognition Forces Underlying Nucleo‐Cytoplasmic Transport
Author(s) -
Rangl Martina,
Ebner Andreas,
Yamada Justin,
Rankl Christian,
Tampé Robert,
Gruber Hermann J.,
Rexach Michael,
Hinterdorfer Peter
Publication year - 2013
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201305359
Subject(s) - nucleoporin , nuclear pore , nuclear transport , envelope (radar) , cytoplasm , molecule , process (computing) , computer science , biophysics , computational biology , chemistry , information retrieval , nanotechnology , biology , microbiology and biotechnology , materials science , cell nucleus , telecommunications , programming language , radar , organic chemistry
Transport forces : To move molecules across the nuclear envelope they have to overcome the selective barrier of the nuclear pore which is formed by nucleoporins (nups) with FG repeats. The molecules are chaperoned by shuttling receptors that interact with FG nups thereby passing the barrier using an unresolved mechanism. This process is explored by single‐molecule force spectroscopy (see picture).