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β 2 ‐Adrenergic Receptor Activation by Agonists Studied with 19 F NMR Spectroscopy
Author(s) -
Horst Reto,
Liu Jeffrey J.,
Stevens Raymond C.,
Wüthrich Kurt
Publication year - 2013
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201305286
Subject(s) - enthalpy , nuclear magnetic resonance spectroscopy , chemistry , spectroscopy , service (business) , computer science , stereochemistry , crystallography , thermodynamics , physics , business , marketing , quantum mechanics
Proteins in slow motion : 19 F NMR studies indicate that equilibria between active and inactive states of the human β 2 ‐adrenergic receptor require extensive structural rearrangements (arrows in picture). This was shown by an enthalpy difference of Δ H o ≈40 kJ mol −1 and a slow exchange rate, with k ex ≪10 s −1 .