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Molecular Mechanism of Prion Protein Oligomerization at Atomic Resolution
Author(s) -
Schlepckow Kai,
Schwalbe Harald
Publication year - 2013
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201305184
Subject(s) - prion protein , mechanism (biology) , chemistry , biophysics , kinetics , pathogenesis , microbiology and biotechnology , biology , medicine , philosophy , physics , disease , epistemology , pathology , quantum mechanics , immunology
Prion protein oligomerization : Despite the crucial role of oligomers during prion protein (PrP) pathogenesis the molecular mechanism of their formation has remained largely elusive. A 2D time‐resolved NMR study which made it possible to characterize the oligomerization kinetics with unprecedented site‐specificity is reported (see picture).