Copper‐Catalyzed Enantioselective Henry Reaction of Enals and Subsequent Iodocyclization: Stereoselective Construction of Chiral Azatricyclic Frameworks | Zendy

Zhou Yirong | Zendy; Zhu Yuequan | Zendy; Yan Shaobai | Zendy; Gong Yuefa | Zendy

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Copper‐Catalyzed Enantioselective Henry Reaction of Enals and Subsequent Iodocyclization: Stereoselective Construction of Chiral Azatricyclic Frameworks

Author(s) -

Zhou Yirong,

Zhu Yuequan,

Yan Shaobai,

Gong Yuefa

Publication year - 2013

Publication title -

angewandte chemie international edition

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 5.831

H-Index - 550

eISSN - 1521-3773

pISSN - 1433-7851

DOI - 10.1002/anie.201305148

Subject(s) - stereoselectivity , intramolecular force , enantioselective synthesis , copper , catalysis , chemistry , combinatorial chemistry , cascade reaction , sequence (biology) , nitroaldol reaction , cascade , stereochemistry , organic chemistry , chromatography , biochemistry

In the frame : A cascade sequence combining an asymmetric Henry reaction and a stereoselective intramolecular iodocyclization provides direct access to an enantioenriched tricyclic hexahydrochromeno[4,3‐ b ]pyrrole framework (see scheme). The Henry reaction is catalyzed by copper in the presence of L1 .

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