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Copper‐Catalyzed Enantioselective Henry Reaction of Enals and Subsequent Iodocyclization: Stereoselective Construction of Chiral Azatricyclic Frameworks
Author(s) -
Zhou Yirong,
Zhu Yuequan,
Yan Shaobai,
Gong Yuefa
Publication year - 2013
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201305148
Subject(s) - stereoselectivity , intramolecular force , enantioselective synthesis , copper , catalysis , chemistry , combinatorial chemistry , cascade reaction , sequence (biology) , nitroaldol reaction , cascade , stereochemistry , organic chemistry , chromatography , biochemistry
In the frame : A cascade sequence combining an asymmetric Henry reaction and a stereoselective intramolecular iodocyclization provides direct access to an enantioenriched tricyclic hexahydrochromeno[4,3‐ b ]pyrrole framework (see scheme). The Henry reaction is catalyzed by copper in the presence of L1 .