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Structure of Active Coagulation Factor XIII Triggered by Calcium Binding: Basis for the Design of Next‐Generation Anticoagulants
Author(s) -
Stieler Martin,
Weber Johannes,
Hils Martin,
Kolb Peter,
Heine Andreas,
Büchold Christian,
Pasternack Ralf,
Klebe Gerhard
Publication year - 2013
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201305133
Subject(s) - safer , calcium , computer science , duty , domain (mathematical analysis) , chemistry , computational biology , world wide web , medicine , political science , biology , computer security , mathematical analysis , mathematics , law
On active duty : The available drugs for cardiovascular diseases can promote blood clotting but can also lead to life‐threatening bleeding episodes. A promising target for the development of safer alternatives is the transglutaminase Factor XIII (FXIII), the active structure of which is presented. The binding and coordination of three calcium ions induce major domain movements in the enzyme upon activation.