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Arimetamycin A: Improving Clinically Relevant Families of Natural Products through Sequence‐Guided Screening of Soil Metagenomes
Author(s) -
Kang HahkSoo,
Brady Sean F.
Publication year - 2013
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201305109
Subject(s) - sequence (biology) , service (business) , computer science , computational biology , information retrieval , heterologous , world wide web , biology , gene , genetics , business , marketing
Sequence‐tag‐guided screening of soil environmental DNA libraries can be used to guide the discovery of new compounds with improved properties. In heterologous expression experiments the eDNA‐derived arm cluster encodes arimetamycin A (see picture), an anthracycline that is more potent than clinically used natural anthracyclines and retains activity against multidrug‐resistant (MDR) cancer cells.