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Binding of a Designed Anti‐Cancer Drug to the Central Cavity of an RNA Three‐Way Junction
Author(s) -
Phongtongpasuk Siriporn,
Paulus Susann,
Schnabl Joachim,
Sigel Roland K. O.,
Spingler Bernhard,
Han Michael J.,
Freisinger Eva
Publication year - 2013
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201305079
Subject(s) - rna , stacking , cylinder , crystallization , base pair , cationic polymerization , drug , chemistry , biophysics , crystallography , biology , dna , mathematics , geometry , biochemistry , gene , polymer chemistry , pharmacology , organic chemistry
Getting to the heart of it : Co‐crystallization of an RNA three‐way junction with a cylindrical di‐iron(II)‐based anti‐cancer drug (green) results in π‐stacking interactions between the cylinder and the central base pairs of the RNA structure. The shape, size, and cationic nature of the cylinder were found to be responsible for this perfect fit. Native gel electrophoresis studies confirmed stabilization of the RNA three‐way junction by the iron(II) cylinder.