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Cucurbit[7]uril Containers for Targeted Delivery of Oxaliplatin to Cancer Cells
Author(s) -
Cao Liping,
Hettiarachchi Gaya,
Briken Volker,
Isaacs Lyle
Publication year - 2013
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201305061
Subject(s) - oxaliplatin , chemistry , urothelial cancer , nanotechnology , cancer research , cancer , materials science , medicine , colorectal cancer , bladder cancer
Stay on target : The cucurbit[7]uril derivative 1 , which bears a covalently attached biotin targeting ligand allows for the efficient delivery of oxaliplatin as its 1 ⋅oxaliplatin complex to cancer cells resulting in enhanced cytotoxicity relative to oxaliplatin alone.