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Chemical Synthesis of Mono‐ and Bis‐Labeled Pre‐MicroRNAs
Author(s) -
Pradère Ugo,
Brunschweiger Andreas,
Gebert Luca F. R.,
Lucic Matije,
Roos Martina,
Hall Jonathan
Publication year - 2013
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201304986
Subject(s) - computer science , service (business) , microrna , world wide web , information retrieval , computational biology , data science , chemistry , biology , biochemistry , business , gene , marketing
A chemical method for the post‐synthetic labeling of pre‐miRNAs on solid support using easily accessible reagents was developed. The procedure was employed to generate a library of 31 pre‐microRNAs carrying labels commonly used in chemical biology, including Cy3, trioxalen, biotin, and BHQ‐1.