Inside Cover: A Chemo‐Enzymatic Approach for Site‐Specific Modification of the RNA Cap (Angew. Chem. Int. Ed. 30/2013) | Zendy

Schulz Daniela | Zendy; Holstein Josephin Marie | Zendy; Rentmeister Andrea | Zendy

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Inside Cover: A Chemo‐Enzymatic Approach for Site‐Specific Modification of the RNA Cap (Angew. Chem. Int. Ed. 30/2013)

Author(s) -

Schulz Daniela,

Holstein Josephin Marie,

Rentmeister Andrea

Publication year - 2013

Publication title -

angewandte chemie international edition

Language(s) - English

Resource type - Reports

SCImago Journal Rank - 5.831

H-Index - 550

eISSN - 1521-3773

pISSN - 1433-7851

DOI - 10.1002/anie.201304978

Subject(s) - messenger rna , cover (algebra) , rna , enzyme , chemistry , click chemistry , computational biology , int , surface modification , biochemistry , combinatorial chemistry , nanotechnology , microbiology and biotechnology , biology , computer science , materials science , engineering , gene , operating system , mechanical engineering

Targeting the mRNA cap by a chemo‐enzymatic approach opens up new possibilities in mRNA isolation and visualization. In their Communication on page 7874 ff. A. Rentmeister and co‐workers present a novel two‐step approach for the regiospecific labeling of the m 7 G cap, a hallmark of eukaryotic mRNAs. They make use of a trimethylguanosine variant capable of transferring reactive groups from AdoMet analogues to the cap. The transferred residues are amenable to click reactions.

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