Back Cover: Design and Synthesis of a Universal Antigen to Detect Brucellosis (Angew. Chem. Int. Ed. 28/2013) | Zendy

Guiard Julie | Zendy; Paszkiewicz Eugenia | Zendy; Sadowska Joanna | Zendy; Bundle David R. | Zendy

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Back Cover: Design and Synthesis of a Universal Antigen to Detect Brucellosis (Angew. Chem. Int. Ed. 28/2013)

Author(s) -

Guiard Julie,

Paszkiewicz Eugenia,

Sadowska Joanna,

Bundle David R.

Publication year - 2013

Publication title -

angewandte chemie international edition

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 5.831

H-Index - 550

eISSN - 1521-3773

pISSN - 1433-7851

DOI - 10.1002/anie.201304907

Subject(s) - antigen , brucella abortus , brucellosis , glycoconjugate , brucella , virology , biology , microbiology and biotechnology , immunology , medicine , biochemistry

Brucellose causes contagious abortion in cattle. The cell‐wall lipopolysaccharide O‐antigen of Brucella species is a homopolymer of 4,6‐dideoxy‐4‐formamido‐α‐ D ‐mannose joined by 1,2 and 1,3 linkages to create A‐ and M‐antigenic determinants, respectively. In their Communication on page 7181 ff. , D. R. Bundle and co‐workers describe a glycoconjugate with both antigenic features. This antigen (red) detects A‐specific (green) and M‐specific (turquoise) antibodies from infected cattle.

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