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Synthesis of Azepine Derivatives by Silver‐Catalyzed [5+2] Cycloaddition of γ ‐Amino Ketones with Alkynes
Author(s) -
Zhou MingBo,
Song RenJie,
Wang ChengYong,
Li JinHeng
Publication year - 2013
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201304902
Subject(s) - cycloaddition , azepine , ring (chemistry) , catalysis , combinatorial chemistry , alkyne , ketone , chemistry , computer science , organic chemistry
Silver forges the ring : A new and practical silver‐catalyzed [5+2] cycloaddition method has been developed for the synthesis of azepines through the formation of four new chemical bonds between a γ‐amino ketone and an alkyne in one step. This method provides a new hetero‐[5+2] cycloaddition strategy for the construction of seven‐membered ring systems.