Twofold Unsymmetrical CH Functionalization of PyrDipSi‐Substituted Arenes: A General Method for the Synthesis of Substituted  meta ‐Halophenols | Zendy

Sarkar Dhruba | Zendy; Melkonyan Ferdinand S. | Zendy; Gulevich Anton V. | Zendy; Gevorgyan Vladimir | Zendy

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Twofold Unsymmetrical CH Functionalization of PyrDipSi‐Substituted Arenes: A General Method for the Synthesis of Substituted meta ‐Halophenols

Author(s) -

Sarkar Dhruba,

Melkonyan Ferdinand S.,

Gulevich Anton V.,

Gevorgyan Vladimir

Publication year - 2013

Publication title -

angewandte chemie international edition

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 5.831

H-Index - 550

eISSN - 1521-3773

pISSN - 1433-7851

DOI - 10.1002/anie.201304884

Subject(s) - surface modification , chemistry , combinatorial chemistry , stereochemistry

And the world is your oyster … Sequential halogenation/oxygenation reactions of 2‐diisopropylsilylpyrimidine‐substituted arenes provide a general and efficient synthesis of substituted meta ‐halophenols from simple aryl iodides (see scheme; Piv=pivaloyl). The products are poised to undergo diverse CC, CN, and CO bond‐forming reactions that enable the transformation of their framework and the introduction of valuable functionalities.

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