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Twofold Unsymmetrical CH Functionalization of PyrDipSi‐Substituted Arenes: A General Method for the Synthesis of Substituted meta ‐Halophenols
Author(s) -
Sarkar Dhruba,
Melkonyan Ferdinand S.,
Gulevich Anton V.,
Gevorgyan Vladimir
Publication year - 2013
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201304884
Subject(s) - surface modification , aryl , halogenation , combinatorial chemistry , chemistry , organic chemistry , alkyl
And the world is your oyster … Sequential halogenation/oxygenation reactions of 2‐diisopropylsilylpyrimidine‐substituted arenes provide a general and efficient synthesis of substituted meta ‐halophenols from simple aryl iodides (see scheme; Piv=pivaloyl). The products are poised to undergo diverse CC, CN, and CO bond‐forming reactions that enable the transformation of their framework and the introduction of valuable functionalities.