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Inside Cover: Enantioselective Isomerization of Primary Allylic Alcohols into Chiral Aldehydes with the tol‐binap/dbapen/Ruthenium(II) Catalyst (Angew. Chem. Int. Ed. 29/2013)
Author(s) -
Arai Noriyoshi,
Sato Keisuke,
Azuma Keita,
Ohkuma Takeshi
Publication year - 2013
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Reports
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201304864
Subject(s) - isomerization , allylic rearrangement , enantioselective synthesis , chemistry , ruthenium , catalysis , binap , medicinal chemistry , organic chemistry , alcohol
Enantioselective isomerization of γ‐substituted primary allylic alcohols into the β‐substituted aldehydes with the [RuCl 2 {(S)‐tol‐binap}{( R )‐dbapen}]/KOH catalyst system is described by T. Ohkuma and co‐workers in their Communication on page 7500 ff. A series of E ‐ and Z ‐configured aromatic and aliphatic allylic alcohols, including a simple primary‐alkyl‐substituted compound ( E )‐3‐methyl‐2‐hepten‐1‐ol, is transformed to the aldehydes in almost enantiomerically pure form.