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Asymmetric Hydrogenation of Ketones with H 2 and Ruthenium Catalysts Containing Chiral Tetradentate S 2 N 2 Ligands
Author(s) -
Patchett Ruth,
Magpantay Iris,
Saudan Lionel,
Schotes Christoph,
Mezzetti Antonio,
Santoro Francesco
Publication year - 2013
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201304844
Subject(s) - chemoselectivity , ruthenium , catalysis , base (topology) , substrate (aquarium) , chemistry , solvent , computer science , combinatorial chemistry , organic chemistry , mathematics , geology , mathematical analysis , oceanography
Getting more for less : In the presence of H 2 and a base, air‐ and moisture‐tolerant Ru II complexes catalyze the hydrogenation of ketones and aldehydes with excellent activity and chemoselectivity, and with enantioselectivity of up to 95 % under mild conditions. The ratio of substrate to catalyst can be lowered to 10 6 :1. The reactions tolerate scale‐up and can be carried out with almost no solvent. A base‐free method is available for base‐sensitive substrates.