Asymmetric Hydrogenation of Ketones with H 2  and Ruthenium Catalysts Containing Chiral Tetradentate S 2 N 2  Ligands | Zendy

Patchett Ruth | Zendy; Magpantay Iris | Zendy; Saudan Lionel | Zendy; Schotes Christoph | Zendy; Mezzetti Antonio | Zendy; Santoro Francesco | Zendy

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Asymmetric Hydrogenation of Ketones with H 2 and Ruthenium Catalysts Containing Chiral Tetradentate S 2 N 2 Ligands

Author(s) -

Patchett Ruth,

Magpantay Iris,

Saudan Lionel,

Schotes Christoph,

Mezzetti Antonio,

Santoro Francesco

Publication year - 2013

Publication title -

angewandte chemie international edition

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 5.831

H-Index - 550

eISSN - 1521-3773

pISSN - 1433-7851

DOI - 10.1002/anie.201304844

Subject(s) - chemoselectivity , ruthenium , catalysis , base (topology) , substrate (aquarium) , chemistry , solvent , computer science , combinatorial chemistry , organic chemistry , mathematics , geology , mathematical analysis , oceanography

Getting more for less : In the presence of H 2 and a base, air‐ and moisture‐tolerant Ru II complexes catalyze the hydrogenation of ketones and aldehydes with excellent activity and chemoselectivity, and with enantioselectivity of up to 95 % under mild conditions. The ratio of substrate to catalyst can be lowered to 10 6 :1. The reactions tolerate scale‐up and can be carried out with almost no solvent. A base‐free method is available for base‐sensitive substrates.

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