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Dehydrogenative Coupling to Enable the Enantioselective Total Synthesis of (−)‐Simaomicin α
Author(s) -
Wang Yizhong,
Wang Chao,
Butler John R.,
Ready Joseph M.
Publication year - 2013
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201304812
Subject(s) - enantioselective synthesis , total synthesis , coupling (piping) , computer science , chemistry , stereochemistry , engineering , organic chemistry , mechanical engineering , catalysis
The anticancer natural product simaomicin α has been synthesized. Asymmetric synthesis allowed the assignment of absolute stereochemistry. The enantiomer of the naturally occurring substance shows potent cytotoxicity towards Gram‐positive bacteria and human cancer cells. Bn=benzyl, BOM=benzyloxymethyl.
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