Total Synthesis of Vinigrol | Zendy

Yang Qingliang | Zendy; Njardarson Jon T. | Zendy; Draghici Cristian | Zendy; Li Fang | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Premium

Total Synthesis of Vinigrol

Author(s) -

Yang Qingliang,

Njardarson Jon T.,

Draghici Cristian,

Li Fang

Publication year - 2013

Publication title -

angewandte chemie international edition

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 5.831

H-Index - 550

eISSN - 1521-3773

pISSN - 1433-7851

DOI - 10.1002/anie.201304624

Subject(s) - stereocenter , total synthesis , cycloaddition , chemistry , fragmentation (computing) , stereochemistry , ring (chemistry) , catalysis , substrate (aquarium) , combinatorial chemistry , organic chemistry , enantioselective synthesis , computer science , biology , ecology , operating system

Carbocyclic cage fight : The substrate‐controlled total synthesis of vinigrol features a strategic oxidative dearomatization/Diels–Alder cycloaddition reaction and a subsequent palladium‐catalyzed cyclization cascade to construct the carbocyclic core. The C4, C9, and C12 stereocenters were installed using either reduction or oxidation reactions, and the diterpenoid core was unraveled by a ring fragmentation reaction.

This content is not available in your region!

Continue researching here.

Having issues? You can contact us here

Accelerating Research