A Disulfide‐Constrained Miniprotein with Striking Tumor‐Binding Specificity Developed by Ribosome Display | Zendy

Zoller Frederic | Zendy; Markert Annette | Zendy; Barthe Philippe | Zendy; Hebling Ulrike | Zendy; Altmann Annette | Zendy; Lindner Thomas | Zendy; Mier Walter | Zendy; Haberkorn Uwe | Zendy

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A Disulfide‐Constrained Miniprotein with Striking Tumor‐Binding Specificity Developed by Ribosome Display

Author(s) -

Zoller Frederic,

Markert Annette,

Barthe Philippe,

Hebling Ulrike,

Altmann Annette,

Lindner Thomas,

Mier Walter,

Haberkorn Uwe

Publication year - 2013

Publication title -

angewandte chemie international edition

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 5.831

H-Index - 550

eISSN - 1521-3773

pISSN - 1433-7851

DOI - 10.1002/anie.201304603

Subject(s) - computational biology , computer science , ribosome , disulfide bond , translation (biology) , chemistry , information retrieval , biology , rna , biochemistry , messenger rna , gene

Fold me to hold me : A specific binding agent against the delta‐like ligand 4 protein, which is expressed in angiogenesis, was identified by ribosome display. Specific tumor binding of this molecular imaging agent depends on the appropriate disulfide connectivity of its scaffold.

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