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A Synthesis of the Chlorosulfolipid Mytilipin A via a Longest Linear Sequence of Seven Steps
Author(s) -
Chung Wonjin,
Carlson Joseph S.,
Bedke D. Karl,
Vanderwal Christopher D.
Publication year - 2013
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201304565
Subject(s) - library science , chemistry , computer science
Magnificent seven : The chlorosulfolipid mytilipin A was synthesized in racemic form in seven steps and in enantioenriched form in eight steps. Key transformations include a highly diastereoselective bromoallylation of a sensitive α,β‐dichloroaldehyde, a kinetic resolution of a vinyl epoxide, a convergent and highly Z ‐selective alkene cross‐metathesis, and a chemoselective and diastereoselective dichlorination of a complex diene.

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