Copper‐Catalyzed Tandem Trifluoromethylation/Semipinacol Rearrangement of Allylic Alcohols | Zendy

Chen ZhiMin | Zendy; Bai Wei | Zendy; Wang ShaoHua | Zendy; Yang BinMiao | Zendy; Tu YongQiang | Zendy; Zhang FuMin | Zendy

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Copper‐Catalyzed Tandem Trifluoromethylation/Semipinacol Rearrangement of Allylic Alcohols

Author(s) -

Chen ZhiMin,

Bai Wei,

Wang ShaoHua,

Yang BinMiao,

Tu YongQiang,

Zhang FuMin

Publication year - 2013

Publication title -

angewandte chemie international edition

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 5.831

H-Index - 550

eISSN - 1521-3773

pISSN - 1433-7851

DOI - 10.1002/anie.201304557

Subject(s) - trifluoromethylation , allylic rearrangement , tandem , chemistry , ketone , quaternary carbon , trifluoromethyl , combinatorial chemistry , catalysis , organic chemistry , materials science , enantioselective synthesis , alkyl , composite material

Tandem jump : A novel copper‐catalyzed tandem trifluoromethylation/semipinacol rearrangement reaction of allylic alcohols has been achieved under mild conditions. This reaction is valuable for the difunctionalization of alkenes through simultaneous construction of a C sp 3CF 3 bond and a quaternary carbon center, and could provide a straightforward strategy for the preparation of α‐quaternary β‐trifluoromethyl ketone derivatives.

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