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Copper‐Catalyzed Tandem Trifluoromethylation/Semipinacol Rearrangement of Allylic Alcohols
Author(s) -
Chen ZhiMin,
Bai Wei,
Wang ShaoHua,
Yang BinMiao,
Tu YongQiang,
Zhang FuMin
Publication year - 2013
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201304557
Subject(s) - trifluoromethylation , allylic rearrangement , tandem , chemistry , ketone , quaternary carbon , trifluoromethyl , combinatorial chemistry , catalysis , organic chemistry , materials science , enantioselective synthesis , alkyl , composite material
Tandem jump : A novel copper‐catalyzed tandem trifluoromethylation/semipinacol rearrangement reaction of allylic alcohols has been achieved under mild conditions. This reaction is valuable for the difunctionalization of alkenes through simultaneous construction of a C sp 3CF 3 bond and a quaternary carbon center, and could provide a straightforward strategy for the preparation of α‐quaternary β‐trifluoromethyl ketone derivatives.