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One Size Does Not Fit All—Bacterial Cell Death by Antibiotics Cannot Be Explained by the Action of Reactive Oxygen Species
Author(s) -
Kuhnert Nikolai
Publication year - 2013
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201304548
Subject(s) - antibiotics , reactive oxygen species , programmed cell death , oxygen , bacterial cell structure , chemistry , cell , microbiology and biotechnology , bacteria , action (physics) , biology , biochemistry , apoptosis , genetics , physics , organic chemistry , quantum mechanics
Back to square one : Two recent studies prove that reactive oxygen species (ROS) are not responsible for bacterial cell death after treatment with antibiotics. The ROS concept cannot be generalized to explain all processes resulting in cell death. The search for the mechanism of action of bacterial antibiotics must thus return to the beginning.