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Versatile Synthesis of Benzothiophenes and Benzoselenophenes by Rapid Assembly of Arylzinc Reagents, Alkynes, and Elemental Chalcogens
Author(s) -
Wu Bin,
Yoshikai Naohiko
Publication year - 2013
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201304546
Subject(s) - chalcogen , reagent , moiety , ring (chemistry) , benzene , combinatorial chemistry , catalysis , chemistry , materials science , organic chemistry
Rapidly aSSembled : The combination of cobalt‐catalyzed migratory arylzincation and copper‐mediated/catalyzed chalcogenative cyclization allows the construction of benzothiophenes and benzoselenophenes from arylzinc reagents, alkynes, and elemental chalcogens. Benzothiophenes and benzoselenophenes diversely functionalized at the benzene ring moiety can be prepared, which are not readily accessible by conventional methods.