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Solid‐Phase Microextraction: A Complementary In Vivo Sampling Method to Microdialysis
Author(s) -
Cudjoe Erasmus,
Bojko Barbara,
de Lannoy Inés,
Saldivia Victor,
Pawliszyn Janusz
Publication year - 2013
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201304538
Subject(s) - microdialysis , solid phase microextraction , chromatography , in vivo , chemistry , gas chromatography–mass spectrometry , mass spectrometry , biology , microbiology and biotechnology
Two's compliment : Solid‐phase microextraction (SPME) was validated against microdialysis (MD) in simultaneous targeted analysis of selected neurotransmitters in brain tissue. Complementary data was obtained from global brain profiling with both methods. MD extracts primarily polar species, and SPME detects semi hydrophobic and hydrophobic compounds, including lipids related to neurodegenerative diseases. RT=retention time.