Premium
Porphyrins for Probing Electrical Potential Across Lipid Bilayer Membranes by Second Harmonic Generation
Author(s) -
Reeve James E.,
Corbett Alex D.,
Boczarow Igor,
Kaluza Wojciech,
Barford William,
Bayley Hagan,
Wilson Tony,
Anderson Harry L.
Publication year - 2013
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201304515
Subject(s) - bilayer , lipid bilayer , membrane , model lipid bilayer , chemistry , chemical physics , nanotechnology , materials science , lipid bilayer phase behavior , biochemistry
Feeling the field! The intensity of second harmonic generation (SHG) from a porphyrin in a lipid bilayer is exceptionally sensitive to electric field, thus indicating that these dyes may be useful probes for electrical signals in excitable cells such as neurons. The porphyrin‐based membrane probe (see picture, not to scale) gives a fast electro‐optic response which is about 5–10 times greater than those of conventional styryl dyes.