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PEGylation and Zwitterionization: Pros and Cons in the Renal Clearance and Tumor Targeting of Near‐IR‐Emitting Gold Nanoparticles
Author(s) -
Liu Jinbin,
Yu Mengxiao,
Ning Xuhui,
Zhou Chen,
Yang Shengyang,
Zheng Jie
Publication year - 2013
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201304465
Subject(s) - pegylation , colloidal gold , nanoparticle , nanotechnology , chemistry , pharmacokinetics , clearance , computer science , combinatorial chemistry , polyethylene glycol , materials science , biochemistry , pharmacology , medicine , urology
Got it PEGged : PEGylation and zwitterionization have distinct effects on the pharmacokinetic and tumor‐targeting properties of luminescent gold nanoparticles (AuNPs), although both strategies lead to effective renal clearance. High tumor‐targeting efficiency and specificity were obtained with PEGylated AuNPs, whereas rapid tumor detection was more readily achieved with zwitterionic AuNPs. HD=hydrodynamic diameter, GS=glutathione.