PEGylation and Zwitterionization: Pros and Cons in the Renal Clearance and Tumor Targeting of Near‐IR‐Emitting Gold Nanoparticles | Zendy

Liu Jinbin | Zendy; Yu Mengxiao | Zendy; Ning Xuhui | Zendy; Zhou Chen | Zendy; Yang Shengyang | Zendy; Zheng Jie | Zendy

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PEGylation and Zwitterionization: Pros and Cons in the Renal Clearance and Tumor Targeting of Near‐IR‐Emitting Gold Nanoparticles

Author(s) -

Liu Jinbin,

Yu Mengxiao,

Ning Xuhui,

Zhou Chen,

Yang Shengyang,

Zheng Jie

Publication year - 2013

Publication title -

angewandte chemie international edition

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 5.831

H-Index - 550

eISSN - 1521-3773

pISSN - 1433-7851

DOI - 10.1002/anie.201304465

Subject(s) - pegylation , colloidal gold , nanoparticle , nanotechnology , chemistry , pharmacokinetics , clearance , computer science , combinatorial chemistry , polyethylene glycol , materials science , biochemistry , pharmacology , medicine , urology

Got it PEGged : PEGylation and zwitterionization have distinct effects on the pharmacokinetic and tumor‐targeting properties of luminescent gold nanoparticles (AuNPs), although both strategies lead to effective renal clearance. High tumor‐targeting efficiency and specificity were obtained with PEGylated AuNPs, whereas rapid tumor detection was more readily achieved with zwitterionic AuNPs. HD=hydrodynamic diameter, GS=glutathione.

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