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Preparation of Functionalized Indoles and Azaindoles by the Intramolecular Copper‐Mediated Carbomagnesiation of Ynamides
Author(s) -
Frischmuth Annette,
Knochel Paul
Publication year - 2013
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201304380
Subject(s) - intramolecular force , theme (computing) , electrophile , computer science , combinatorial chemistry , chemistry , world wide web , organic chemistry , catalysis
Variations on a theme : A mild and general intramolecular copper‐mediated carbomagnesiation procedure for the synthesis of functionalized indoles as well as 4‐, 5‐, 6‐, and 7‐azaindoles starts from readily available ynamides. Subsequent reactions with various electrophiles provides polyfunctional N‐heterocycles in good yields.