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Cover Picture: Organocatalysis by Neutral Multidentate Halogen‐Bond Donors (Angew. Chem. Int. Ed. 27/2013)
Author(s) -
Kniep Florian,
Jungbauer Stefan H.,
Zhang Qi,
Walter Sebastian M.,
Schindler Severin,
Schnapperelle Ingo,
Herdtweck Eberhardt,
Huber Stefan M.
Publication year - 2013
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Reports
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201304261
Subject(s) - halogen , halogen bond , chemistry , ketene , lewis acids and bases , denticity , organocatalysis , silylation , catalysis , halide , medicinal chemistry , polymer chemistry , combinatorial chemistry , photochemistry , organic chemistry , enantioselective synthesis , crystal structure , alkyl
Neutral multidentate halogen‐bond donors (halogen‐based Lewis acids) can be used as organocatalysts in a halide abstraction reaction. In their Communication on page 7028 ff., S. M. Huber et al. describe the halogen‐bond‐catalyzed reaction of 1‐chloroisochroman with ketene silyl acetals. The organocatalytic activity crucially depends on the iodine substituents of the halogen‐bond donors, and hidden acid catalysts can be ruled out with high probability.