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Inside Back Cover: Direct Asymmetric Vinylogous Aldol Reaction of Allyl Ketones with Isatins: Divergent Synthesis of 3‐Hydroxy‐2‐Oxindole Derivatives (Angew. Chem. Int. Ed. 26/2013)
Author(s) -
Zhu Bo,
Zhang Wen,
Lee Richmond,
Han Zhiqiang,
Yang Wenguo,
Tan Davin,
Huang KuoWei,
Jiang Zhiyong
Publication year - 2013
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Reports
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201304259
Subject(s) - aldol reaction , oxindole , chemistry , enantioselective synthesis , nucleophile , total synthesis , catalysis , combinatorial chemistry , organic chemistry , stereochemistry
Acyclic allyl ketones are rarely employed as nucleophiles in vinylogous reactions owing to the low electron density at the γ position of the dienolates. In their Communication on page 6666 ff., K.‐W. Huang, Z. Jiang, and co‐workers demonstrate that with a proper catalyst design, a direct enantioselective vinylogous aldol reaction of allyl ketones to isatins can be achieved with a broad scope for the collective synthesis of 3‐hydroxy‐2‐oxindoles which have important biological activities.