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ESI Hydrogen/Deuterium Exchange Can Count Chemical Forms of Heteroatom‐Bound Hydrogen
Author(s) -
Tittebrandt Sebastian,
EdelsonAverbukh Marina,
Spengler Bernhard,
Lehmann Wolf D.
Publication year - 2013
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201304249
Subject(s) - deuterium , hydrogen–deuterium exchange , hydrogen , heteroatom , chemistry , service (business) , computer science , organic chemistry , physics , atomic physics , ring (chemistry) , economy , economics
Out for the count : Hydrogen–deuterium exchange (HDX) performed in ESI droplets can distinguish chemically distinct forms of labile hydrogen. NanoESI exchanged mainly O‐bound hydrogen atoms, whereas ESI also exchanged a subset of N‐bound hydrogen atoms. The exchange behavior could be predicted. Thus, the combined use of nanoESI‐ and ESI‐HDX can be applied to count chemically different forms of labile hydrogen atoms.