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Sugar‐Modified Foldamers as Conformationally Defined and Biologically Distinct Glycopeptide Mimics
Author(s) -
Siriwardena Aloysius,
Pulukuri Kiran Kumar,
Kandiyal Pancham S.,
Roy Saumya,
Bande Omprakash,
Ghosh Subhash,
Garcia Fernández José Manuel,
Ariel Martin Fernando,
Ghigo JeanMarc,
Beloin Christophe,
Ito Keigo,
Woods Robert J.,
Ampapathi Ravi Sankar,
Chakraborty Tushar Kanti
Publication year - 2013
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201304239
Subject(s) - glycopeptide , chemistry , mannose , sugar , stereochemistry , biochemistry , antibiotics
To fold or not to fold? It is shown that attached sugars play a defining role in the conformations adopted by a pair of novel SAA‐derived foldamers in water and that these differences are reflected in the contrasting interactions of these glycofoldamers with various biological targets. C green, O red, N blue, H gray; yellow oval=mannose.