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Back Cover: Mix to Validate: A Facile, Reversible PEGylation for Fast Screening of Potential Therapeutic Proteins In Vivo (Angew. Chem. Int. Ed. 27/2013)
Author(s) -
Kim Tae Hyung,
Swierczewska Magdalena,
Oh Yumin,
Kim AeRyon,
Jo Dong Gyu,
Park Jae Hyung,
Byun Youngro,
SadeghNasseri Scheherazade,
Pomper Martin G.,
Lee Kang Choon,
Lee Seulki
Publication year - 2013
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201304233
Subject(s) - pegylation , in vivo , conjugate , ethylene glycol , chemistry , combinatorial chemistry , ex vivo , cover (algebra) , biophysics , computational biology , biochemistry , polyethylene glycol , in vitro , biology , organic chemistry , engineering , mathematical analysis , microbiology and biotechnology , mathematics , mechanical engineering
Increasing the half‐life of therapeutic proteins in a specific, fast, and reliable way could greatly benefit the discovery of novel protein drugs. In their Communication on page 6880 ff. , K. C. Lee, S. Lee, and co‐workers conjugate Ni‐NTA to poly(ethylene glycol) and then label oligohistidine‐tagged therapeutic proteins to improve their stability in vivo without compromising bioactivity.

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