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Water‐Soluble Polymers Coupled with Glycopeptide Antigens and T‐Cell Epitopes as Potential Antitumor Vaccines
Author(s) -
Nuhn Lutz,
Hartmann Sebastian,
Palitzsch Björn,
Gerlitzki Bastian,
Schmitt Edgar,
Zentel Rudolf,
Kunz Horst
Publication year - 2013
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201304212
Subject(s) - epitope , glycopeptide , methacrylamide , toxoid , muc1 , chemistry , antigen , antibody , microbiology and biotechnology , biochemistry , biology , immunology , immunization , polymer , copolymer , acrylamide , organic chemistry , antibiotics
Highly decorated : Tumor‐associated MUC1 glycopeptide and tetanus toxoid T‐cell epitope P2 can be attached to water‐soluble poly( N ‐(2‐hydroxypropyl)methacrylamide) carriers by orthogonal ligation techniques. Fully synthetic vaccine A with additional nanostructure‐promoting domains induced antibodies that exhibit high affinity to tumor cells.