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Back Cover: The Fatty Acid Composition of Diacylglycerols Determines Local Signaling Patterns (Angew. Chem. Int. Ed. 24/2013)
Author(s) -
Nadler André,
Reither Gregor,
Feng Suihan,
Stein Frank,
Reither Sabine,
Müller Rainer,
Schultz Carsten
Publication year - 2013
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201304203
Subject(s) - orchestration , cover (algebra) , chemistry , fatty acid , cell signaling , biochemistry , composition (language) , intracellular , kinase , int , signal transduction , microbiology and biotechnology , biophysics , biology , computer science , engineering , visual arts , mechanical engineering , art , musical , linguistics , philosophy , operating system
Photoactivatable or “caged” derivatives of signaling molecules are important tools for manipulating intracellular events with spatial and temporal resolution. In their Communication on page 6330 ff., C. Schultz and co‐workers demonstrate that regionally limited photoactivation simultaneously leads to a local protein kinase C and a global calcium response. Surprisingly, the orchestration of these effects seems to depend on the fatty acid composition of the released lipid.