Catalytic Enantioselective Iodoetherification of Oximes | Zendy

Tripathi Chandra Bhushan | Zendy; Mukherjee Santanu | Zendy

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Catalytic Enantioselective Iodoetherification of Oximes

Author(s) -

Tripathi Chandra Bhushan,

Mukherjee Santanu

Publication year - 2013

Publication title -

angewandte chemie international edition

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 5.831

H-Index - 550

eISSN - 1521-3773

pISSN - 1433-7851

DOI - 10.1002/anie.201304173

Subject(s) - enantioselective synthesis , stereocenter , yield (engineering) , thiourea , catalysis , chemistry , organocatalysis , organic chemistry , combinatorial chemistry , computer science , materials science , metallurgy

Organocatalysis : The first catalytic enantioselective iodoetherification of oximes is developed using commercially available N ‐iodosuccinimide. In the presence of a dihydrocinchonidine‐derived thiourea (10 mol %), β,γ‐unsaturated oximes undergo facile iodoetherification to produce Δ 2 ‐isoxazolines containing a quaternary stereogenic center generally in high yield with good to excellent enantioselectivity.

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