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Phosphoramidate Tantalum Complexes for Room‐Temperature CH Functionalization: Hydroaminoalkylation Catalysis
Author(s) -
Garcia Pierre,
Lau Ying Yin,
Perry Mitchell R.,
Schafer Laurel L.
Publication year - 2013
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201304153
Subject(s) - phosphoramidate , tantalum , chemistry , catalysis , substrate (aquarium) , structural isomer , combinatorial chemistry , trimethylsilyl , computer science , organic chemistry , stereochemistry , geology , oceanography
A cooled reaction : Phosphoramidate–ClTaMe 3 complexes promote the first example of room‐temperature hydroaminoalkylation catalysis. This reaction can be realized under solvent‐free conditions and with challenging substrates such as styrenes and dialkyl amines. When using a vinylsilane substrate, for the first time the linear regioisomer is obtained preferentially using a Group 5 metal. TBS= tert ‐butyldimethylsilyl, TMS=trimethylsilyl.