Phosphoramidate Tantalum Complexes for Room‐Temperature CH Functionalization: Hydroaminoalkylation Catalysis | Zendy

Garcia Pierre | Zendy; Lau Ying Yin | Zendy; Perry Mitchell R. | Zendy; Schafer Laurel L. | Zendy

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Phosphoramidate Tantalum Complexes for Room‐Temperature CH Functionalization: Hydroaminoalkylation Catalysis

Author(s) -

Garcia Pierre,

Lau Ying Yin,

Perry Mitchell R.,

Schafer Laurel L.

Publication year - 2013

Publication title -

angewandte chemie international edition

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 5.831

H-Index - 550

eISSN - 1521-3773

pISSN - 1433-7851

DOI - 10.1002/anie.201304153

Subject(s) - phosphoramidate , tantalum , chemistry , catalysis , substrate (aquarium) , structural isomer , combinatorial chemistry , trimethylsilyl , computer science , organic chemistry , stereochemistry , geology , oceanography

A cooled reaction : Phosphoramidate–ClTaMe 3 complexes promote the first example of room‐temperature hydroaminoalkylation catalysis. This reaction can be realized under solvent‐free conditions and with challenging substrates such as styrenes and dialkyl amines. When using a vinylsilane substrate, for the first time the linear regioisomer is obtained preferentially using a Group 5 metal. TBS= tert ‐butyldimethylsilyl, TMS=trimethylsilyl.

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