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Catalytic, Enantioselective, and Highly Chemoselective Bromocyclization of Olefinic Dicarbonyl Compounds
Author(s) -
Zhao Yi,
Jiang Xiaojian,
Yeung YingYeung
Publication year - 2013
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201304107
Subject(s) - enantioselective synthesis , thiocarbamate , moiety , chemistry , bifunctional , catalysis , amine gas treating , organic chemistry , combinatorial chemistry
Overriding preferences : An amine–thiocarbamate catalyst can mediate the facile, efficient, and highly enantioselective bromocyclization of olefinic 1,3‐dicarbonyl compounds. In the presence of the bifunctional catalyst, the bromination occurs chemoselectively at the olefinic moiety rather than at the carbon atom in the α‐position to the carbonyl units.