Access to β‐Keto Esters by Palladium‐Catalyzed Carbonylative Coupling of Aryl Halides with Monoester Potassium Malonates | Zendy

Korsager Signe | Zendy; Nielsen Dennis U. | Zendy; Taaning Rolf H. | Zendy; Skrydstrup Troels | Zendy

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Access to β‐Keto Esters by Palladium‐Catalyzed Carbonylative Coupling of Aryl Halides with Monoester Potassium Malonates

Author(s) -

Korsager Signe,

Nielsen Dennis U.,

Taaning Rolf H.,

Skrydstrup Troels

Publication year - 2013

Publication title -

angewandte chemie international edition

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 5.831

H-Index - 550

eISSN - 1521-3773

pISSN - 1433-7851

DOI - 10.1002/anie.201304072

Subject(s) - aryl , palladium , chemistry , halide , carbon monoxide , carbonylation , catalysis , stoichiometry , potassium , organic chemistry , medicinal chemistry , combinatorial chemistry , alkyl

New tricks for an old dog : The Pd‐catalyzed carbonylative α‐arylation of monoethyl potassium malonates with aryl bromides and reactive aryl chlorides provides a simple and direct route to aryl β‐ketoesters. Because only stoichiometric amounts of carbon monoxide are employed, the method is ideal for the introduction of carbon isotopes into more complex structures.

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