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Access to β‐Keto Esters by Palladium‐Catalyzed Carbonylative Coupling of Aryl Halides with Monoester Potassium Malonates
Author(s) -
Korsager Signe,
Nielsen Dennis U.,
Taaning Rolf H.,
Skrydstrup Troels
Publication year - 2013
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201304072
Subject(s) - aryl , palladium , chemistry , halide , carbon monoxide , carbonylation , catalysis , stoichiometry , potassium , organic chemistry , medicinal chemistry , combinatorial chemistry , alkyl
New tricks for an old dog : The Pd‐catalyzed carbonylative α‐arylation of monoethyl potassium malonates with aryl bromides and reactive aryl chlorides provides a simple and direct route to aryl β‐ketoesters. Because only stoichiometric amounts of carbon monoxide are employed, the method is ideal for the introduction of carbon isotopes into more complex structures.