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Enantioselective Synthesis of Quaternary Carbon Stereogenic Centers through Copper‐Catalyzed Conjugate Additions of Aryl‐ and Alkylaluminum Reagents to Acyclic Trisubstituted Enones
Author(s) -
Dabrowski Jennifer A.,
Villaume Matthew T.,
Hoveyda Amir H.
Publication year - 2013
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201304035
Subject(s) - stereocenter , conjugate , enantioselective synthesis , reagent , aryl , alkyl , catalysis , quaternary carbon , chemistry , combinatorial chemistry , carbon fibers , organic chemistry , mathematics , mathematical analysis , algorithm , composite number
Acyclic quaternary carbons by conjugate addition : The first examples of catalytic enantioselective conjugate additions of aryl and alkyl units that generate acyclic all‐carbon quaternary stereogenic centers have been developed (see scheme). The requisite organoaluminum reagents can either be prepared in situ from easily available organolithiums or purchased at low cost.